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I am a visiting associate professor in the Meinig School of Biomedical Engineering, and will join the faculty at Cornell University in July 2022. I received a Ph.D. in Applied Physics from Cornell University, where I worked on nonlinear optical microscopy in the laboratory of Watt Webb. For postdoctoral studies, I was a Croucher Fellow studying cortical microcircuits with Yang Dan at the University of California, Berkeley. Since 2013, I have been a faculty member in the Department of Psychiatry at Yale University.
My lab applies systems neuroscience and neuroengineering approaches to the study of mental health. We develop optical imaging techniques to visualize neural dynamics in awake mice. We design quantitative decision-making paradigms to characterize behavior. We often complement the imaging and behavioral experiments with other molecular, electrophysiological, optogenetic, and computational methods.
Current effort in the lab is directed towards two topics: (1) Drug action in the brain: Psychiatric drugs exert powerful effects in humans characterized by altered perception, cognition, and mood. The lab studies the action of psychoactive drugs, including ketamine and serotonergic psychedelics such as psilocybin, on the function and connectivity of neurons in the frontal cortex. (2) Decision-making: Animals use past choice and reward history to guide their current decisions. We are interested in how neural circuits may implement reinforcement learning, and whether reward learning dysfunctions may be a useful metric to quantify neuropsychiatric conditions.
My lab applies systems neuroscience and neuroengineering approaches to the study of mental health. We develop optical imaging techniques to visualize neural dynamics in awake mice. We design quantitative decision-making paradigms to characterize behavior. We often complement the imaging and behavioral experiments with other molecular, electrophysiological, optogenetic, and computational methods.
Current effort in the lab is directed towards two topics: (1) Drug action in the brain: Psychiatric drugs exert powerful effects in humans characterized by altered perception, cognition, and mood. The lab studies the action of psychoactive drugs, including ketamine and serotonergic psychedelics such as psilocybin, on the function and connectivity of neurons in the frontal cortex. (2) Decision-making: Animals use past choice and reward history to guide their current decisions. We are interested in how neural circuits may implement reinforcement learning, and whether reward learning dysfunctions may be a useful metric to quantify neuropsychiatric conditions.
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论文共 38 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Biological Psychiatryno. 9 (2023): S57-S57
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Sarah J. Jefferson,Ian Gregg,Mark Dibbs,Clara Liao, Hao Wu,Pasha A. Davoudian,Samuel C. Woodburn, Patrick H. Wehrle, Jeffrey S. Sprouse,Alexander M. Sherwood, Alfred P. Kaye,Christopher Pittenger,
biorxiv(2023)
Natureno. 7966 (2023): 677-678
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Farid Aboharb,Pasha Davoudian,Ling-Xiao Shao, Jocelyne Rondeau, Alexander Sherwood,Alfred Kaye,Alex Kwan
NEUROPSYCHOPHARMACOLOGY (2023): 332-332
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bioRxiv : the preprint server for biologyno. 6 (2023): ENEURO.0019-23.2023
Hongli Wang,Alex C. Kwan
Neuroscience & Biobehavioral Reviews (2023): 105158-105158
W. Sharon Zheng,Yajun Zhang, Roger E. Zhu,Peng Zhang,Smriti Gupta,Limeng Huang, Deepika Sahoo,Kaiming Guo,Matthew E. Glover,Krishna C. Vadodaria,Mengyao Li,Tongrui Qian,
bioRxiv (2022)
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