He is an honorary Principal Fellow in the Sir Peter MacCallum Department of Oncology at Peter MacCallum Cancer Centre.
His current clinical positions are Deputy Director of Gastroenterology at Royal Melbourne Hospital, Gastroenterologist at Peter MacCallum Cancer Centre and Epworth HealthCare.

Prof Boussioutas leads a research program in Upper Gastrointestinal Cancer through two laboratories. He has published in journals including Nature, Cancer Cell, New England Journal of Medicine, Gastroenterology in the field of Gastrointestinal oncology.
His research encompasses a number of disciplines including: population health and screening; use of novel technologies to aid early detection of cancer and; genomics in the investigation of molecular pathology of gastric cancer. He also has an active research program into colorectal cancer through his leadership at the Familial Cancer Clinic at Peter MacCallum Cancer Centre and collaborations with the School of Population Health at University of Melbourne.