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We aimed to study the effects of the TGF-beta pathway in breast cancer stem cell (BCSC) regulation. To define a role of the TGF-beta pathway in the regulation of human BCSCs, we have analyzed a panel of breast cancer cell lines that represent the molecular heterogeneity present in primary tumors. In vitro and in vivo assays showed that TGF-beta differentially regulates BCSCs populations of cell lines from different transcriptional profile clusters (Neve et al. 2006). A transcriptomic approach was performed to identify a TGF-beta self-renewal promoting gene signature. An integrated bioinformatic analysis found this signature to be a prognostic pathway signature in ER-/basal human breast cancer. We are now focusing on trying to unravel the underlying molecular mechanisms of the dual effects of TGF-beta in BCSCs.
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Frederic Lluis, Youssef Ellaithy,Willy Antoni Abreu de Oliveira, Anirudh Pabba,Alessandra Qualizza,Francois Richard,Paraskevi Athanasouli, Carla Rios Luci,Wout De Wispelaere,Larissa Mourao, Sian Hamer,Stijn Moens,
biorxiv(2024)
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Albert Gris-Oliver,Marta Palafox, Laia Monserrat,Fara Brasó-Maristany, Andreu Òdena,Mònica Sánchez-Guixé,Yasir H. Ibrahim,Guillermo Villacampa,Judit Grueso,Mireia Parés,Marta Guzmán,Olga Rodríguez,
openalex(2023)
crossref(2023)
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Ian G Cannell,Kirsty Sawicka, Isabella Pearsall, Sophia A Wild, Lauren Deighton,Sarah M Pearsall,Giulia Lerda,Fadwa Joud,Showkhin Khan,Alejandra Bruna,Kathryn L Simpson,Claire M Mulvey,
Cell reportsno. 8 (2023): 112791-112791
crossref(2023)
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