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An internationally recognized pioneer in the field of human cancer genetics, Dr. de la Chapelle’s research focused on the mapping, cloning and characterization of genes that predispose individuals to cancer. His findings led to important discoveries about the molecular and genetic nature of cancer, setting the stage for the development of innovative treatments.
One of Dr. de la Chapelle’s most important achievements in cancer genetics was helping to identify and map four genes (mismatch repair genes) that cause Lynch syndrome (LS), an inherited disorder that makes certain families susceptible to colorectal cancer. By discerning that this susceptibility results from a damaged cell’s inability to repair its DNA, he discovered a new cancer-causing mechanism. This work paved the way for identification, diagnosis and cancer prevention in patients with mismatch repair mutations.
One of Dr. de la Chapelle’s most important achievements in cancer genetics was helping to identify and map four genes (mismatch repair genes) that cause Lynch syndrome (LS), an inherited disorder that makes certain families susceptible to colorectal cancer. By discerning that this susceptibility results from a damaged cell’s inability to repair its DNA, he discovered a new cancer-causing mechanism. This work paved the way for identification, diagnosis and cancer prevention in patients with mismatch repair mutations.
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