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Our laboratory focuses on analysis of the interactions between the G proteins and their protein targets at a molecular and structural level with the goal of understanding how these interactions lead to alterations in protein and cellular activities. Another goal is to connect the biochemical information about protein interaction interfaces to specific cellular physiologies. To this end we are developing antagonists of specific G protein interactions and using these tools to probe the functions of those interactions in living cells. This approach will help to define the roles of specific G protein interactions in physiological processes and as potential targets for therapeutic intervention in cardiovascular disease or cancer.
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论文共 268 篇作者统计合作学者相似作者
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Patrick Martin, Emily A Kurth, David Budean, Nathalie Momplaisir, Elaine Qu, Jennifer M Simien, Grace E Orellana, Chad A Brautigam,Alan V Smrcka, Ellinor Haglund
PloS oneno. 4 (2024): e0298418-e0298418
Xiaohuan Chen, Nicole A Bell, Breanna L Coffman,Agustin A Rabino,Rafael Garcia-Mata,Paul J Kammermeier,David I Yule,Daniel Axelrod,Alan V Smrcka,David R Giovannucci,Arun Anantharam
bioRxiv : the preprint server for biology (2024)
Journal of Biological Chemistrypp.107211-107211, (2024)
JOURNAL OF NEUROENDOCRINOLOGY (2023)
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
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bioRxiv : the preprint server for biology (2023)
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
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bioRxiv : the preprint server for biology (2023)
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