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个人简介
Dr. Remaley’s research has focused on the beneficial role of high-density lipoprotein (HDL), the so-called “good cholesterol.” HDL, which is a complex of the protein apoA-I with phospholipids, removes excess cholesterol from peripheral tissues, such as the arterial wall, and transports it to the liver and intestine for excretion from the body. It has been shown that this process—the reverse cholesterol transport pathway—can be markedly stimulated by infusing HDL made with either purified or recombinant apoA-I and phospholipids. HDL infusion has been proposed as an acute therapy for patients with acute coronary syndrome who are at imminent risk for developing myocardial infarction. His laboratory has developed small synthetic peptide mimetics of apoA-I, and like the full-length protein, these peptides mobilize excess cholesterol from cells and have been shown to reduce atherosclerosis and inflammation in animal models. One of the peptides developed by his laboratory has been licensed to an outside company and is now undergoing pre-clinical toxicology studies for evaluation as a possible new therapy.
研究兴趣
论文共 593 篇作者统计合作学者相似作者
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Jennifer Casiano Matos, Kaneemozhe Harichandran,Jingrong Tang, Denis O. Sviridov,Giacomo Sidoti Migliore,Motoshi Suzuki, Lisa R. Olano, Alvaro Hobbs,Ashish Kumar, Myeisha U. Paskel,Mattia Bonsignori,Altaira D. Dearborn,
JOURNAL OF VIROLOGYno. 1 (2024): e0084923-e0084923
Rebecca O. Oyetoro, Katherine M. Conners,Jungnam Joo,Sarah Turecamo,Maureen Sampson,Anna Wolska,Alan T. Remaley,James D. Otvos, Margery A. Connelly,Nicholas B. Larson,Suzette J. Bielinski, Maryam Hashemian,
Tatiana C. Coverdell,Maureen Sampson,Rafael Zubirán,Anna Wolska,Leslie J. Donato,Jeff W. Meeusen,Allan S. Jaffe,Alan T. Remaley
Lipids in Health and Diseaseno. 1 (2024): 1-11
JACC-HEART FAILUREno. 2 (2024): 290-300
Sarah Turecamo, Carolina G. Downie,Anna Wolska, Samia Mora,James D. Otvos,Margery A. Connelly,Alan T. Remaley, Katherine M. Conners,Jungnam Joo,Maureen Sampson,Suzette J. Bielinski,Joseph J. Shearer,
Anupam K. Mondal,Daniel C. Brock,Sheldon Rowan,Zhi-Hong Yang,Krishna Vamsi Rojulpote,Kelsey M. Smith,Sarah G. Francisco,Eloy Bejarano,Milton A. English, Amy Deik, Sarah Jeanfavre, Clary B. Clish,
iScienceno. 2 (2024): 108979-108979
EXPERT REVIEW OF MOLECULAR DIAGNOSTICSno. 1-2 (2024): 123-133
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