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What began to fascinate him was the fact that a potent growth transforming agent could be carried by most individuals as an apparently asymptomatic infection. This led to two lines of investigation. One explored the notion that EBV could adopt different forms of latency in vivo to that displayed in the in vitro transformation system, an idea that ultimately led to the discovery of distinct patterns of viral antigen expression in the different types of EBV-associated tumours. The other, initiated while on sabbatical in Australia with his colleague Denis Moss, concerned the role of immune T cells in controlling EBV infection and the consequences of T cell suppression on the virus-host balance. Both lines of investigation have been developed for over two decades at the University of Birmingham, and are now leading to clinical trials of a vaccine designed to boost T cell immunity to viral antigens expressed in EBV-positive tumours.
Professor Rickinson has received numerous honours. He is an elected Fellow of the Royal Society (UK National Academy of Science), a Founder Fellow of the UK Academy of Medical Sciences, and Honorary Fellow of the Royal College of Physicians, London.. He serves on the Editorial Board of several important journals and is on the Scientific Advisory Board of many research centres both in UK and worldwide. He has numerous publications and his work has had a tremendous impact on elucidating the biology and immunology of EBV infection and development of therapeutic vaccines to target EBV-associated malignancies.
Professor Rickinson has received numerous honours. He is an elected Fellow of the Royal Society (UK National Academy of Science), a Founder Fellow of the UK Academy of Medical Sciences, and Honorary Fellow of the Royal College of Physicians, London.. He serves on the Editorial Board of several important journals and is on the Scientific Advisory Board of many research centres both in UK and worldwide. He has numerous publications and his work has had a tremendous impact on elucidating the biology and immunology of EBV infection and development of therapeutic vaccines to target EBV-associated malignancies.
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Frontiers in Oncology (2019)
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Leah Fitzsimmons, Rachel Cartlidge,Catherine Chang, Nenad Sejic,Laura C. A. Galbraith,Chathura D. Suraweera,Deborah Croom-Carter,Grant Dewson,Rosemary J. Tierney,Andrew I. Bell, Clare Shannon-Lowe,Marco J. Herold,
Philosophical Transactions of the Royal Society Bno. 1732 (2017): 20160271-20160271
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