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Research Interests.
The Alam laboratory’s primary research is focused on understanding the biophysical properties of antigen-antibody binding and the molecular events of early B cell activation using the HIV-1 broadly neutralizing antibody (bnAb) lineage models. We are studying how HIV-1 Envelope proteins of varying affinities are sensed by B cells expressing HIV-1 bnAbs or their germline antigen receptors and initiate early signaling events for their activation. In the long-term these studies will facilitate design and pre-selection of immunogens for testing in animal models and accelerate HIV-1 vaccine development.
Current research include the following NIAID-funded projects
The Alam laboratory’s primary research is focused on understanding the biophysical properties of antigen-antibody binding and the molecular events of early B cell activation using the HIV-1 broadly neutralizing antibody (bnAb) lineage models. We are studying how HIV-1 Envelope proteins of varying affinities are sensed by B cells expressing HIV-1 bnAbs or their germline antigen receptors and initiate early signaling events for their activation. In the long-term these studies will facilitate design and pre-selection of immunogens for testing in animal models and accelerate HIV-1 vaccine development.
Current research include the following NIAID-funded projects
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CELLno. 1 (2024): 79-94.e24
Science advancesno. 5 (2024): eadj0396-eadj0396
Current Opinion in HIV and AIDSno. 6 (2023): 300-308
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bioRxiv : the preprint server for biology (2023)
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Ashley N Nelson,Xiaoying Shen, Sravani Vekatayogi, Shiyu Zhang,Gabriel Ozorowski,Maria Dennis,Leigh M Sewall, Emma Milligan, Dominique Davis,Kaitlyn A Cross,Yue Chen,Jelle van Schooten,
bioRxiv : the preprint server for biology (2023)
JOURNAL OF VIROLOGYno. 12 (2023): e0107023-e0107023
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