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职业迁徙
个人简介
We are exposed to various health hazards. These are found in routine life styles, diets, environmental pollutants and occupational settings. To build rational preventive measures, both susceptive genetic determinants and environmental factors should be taken into account. When our global environment was clean, a phenotype susceptible to dioxins or to formaldehyde had never emerged as a public health issue. However, as our environment is contaminated with chemicals, phenotypes associated with chemical exposures have emerged as an important public health issue: for example formaldehyde causes asthma in some people while it does not in others. In short, changes in environment always have revealed new phenotypes and brought new public health issues. We therefore consider it critical to dissect gene-environmental interactions in a dynamic state. On this basis, we would like to conduct public health practices. Currently, following projects are ongoing. The first one is to find susceptible genes for Moyamoya disease (figures). We have also analyzed in our laboratory from a viewpoint of preventive medicine against brain infarction and breeding in the childhood. In the second project, we are assessing levels of exposure to persistent organic pollutants in a 30-year span. In this project, we are building the Environmental Sample Bank which is open to the public. In parallel we are investigating pharmacological actions of organofluorine compounds at molecular levels. In the last project, we are working on chronic kidney disease (CKD) in Sri Lanka. In this project we are investigating the mechanism and the prevention of CKD. We have still other ongoing projects related to common diseases such as diabetes.
研究兴趣
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Kazuyoshi Furukawa, Kahori Okamoto-Matsuda,Kouji H Harada,Mutsuko Minata,Toshiaki Hitomi,Hatasu Kobayashi,Akio Koizumi
Journal of Stroke and Cerebrovascular Diseasesno. 2 (2024): 107513-107513
Yukiko Fujii,Kouji H. Harada,Yoshiko Ito, Miho Yoshitake, Chiharu Matsunobu,Yoshihisa Kato,Chiho Ohta,Nobuyuki Koga,Osamu Kimura,Tetsuya Endo,Akio Koizumi,Koichi Haraguchi
The Lancet Neurologyno. 8 (2022): 747-758
Biochemical and biophysical research communications (2022): 62-68
Nagie Tosaki,Hideyuki Okada,Yoshihiro Uno,Takahide Ikeda, Ayaka Kato, Risako Kabata,Hiroko Okuda,Kouji Harada,Akio Koizumi,Hiroyuki Morita
Nihon Naika Gakkai Zasshino. 1 (2022): 89-95
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