Our group is interested in investigating the mechanistic basis of ovarian cancer development, progression and resistance to therapy. We are interested in understanding the key initiating factors that determine how precursor cells develop into tumours and how such tumours evolve under therapeutic selection. Our aim is to translate such understanding into early detection methods for women who are at high risk of ovarian cancer and to develop novel therapeutic approaches to prevent recurrence of ovarian cancers following primary treatment. We combine novel surgical techniques in prospective clinical trials with mechanistic laboratory investigations to achieve our goals.