基本信息
浏览量:45
职业迁徙
个人简介
The maintenance of a complete and undamaged genome is critical for survival. Because DNA is continuously exposed to genotoxic stress, cells have evolved mechanisms that are specialized for correcting different types of DNA damage. These mechanisms play essential roles in the maintenance of genome integrity and their deficiencies have been associated with ageing and cancer.
The mechanisms that maintain genome stability show amazing complexity and our laboratory is interested in discovering unknown aspects of their function. We are particularly interested in a large family of helicase-like proteins called SNF2 ATPases, characterised by the presence of a specific ATPase domain. SNF2 ATPases are widespread among eukaryotes, but are also represented in bacteria and archaea. They are a functionally heterogeneous family of proteins and regulate diverse nuclear functions, including transcription, DNA replication, DNA repair and recombination. Moreover, many SNF2 family members have been linked to human disease and cancer. Their role in human pathologies is documented by several developmental disorders associated with mutations in SNF2 ATPase genes. In addition, SNF2 ATPases have emerged as contributing factors in a variety of human cancers. Different SNF2 ATPases play different roles in cancer: whereas some act as tumour suppressors, others have oncogenic functions.
We are also interested in identifying novel factors involved in the maintenance of genome stability outside of the SNF2 ATPase family. We use a multidisciplinary approach to study these factors at a biochemical, cellular, and physiological level. Our aim is to provide a detailed picture of their function and improve our understanding of fundamental cellular mechanisms that impact on genome stability and play a role in human disease.
The mechanisms that maintain genome stability show amazing complexity and our laboratory is interested in discovering unknown aspects of their function. We are particularly interested in a large family of helicase-like proteins called SNF2 ATPases, characterised by the presence of a specific ATPase domain. SNF2 ATPases are widespread among eukaryotes, but are also represented in bacteria and archaea. They are a functionally heterogeneous family of proteins and regulate diverse nuclear functions, including transcription, DNA replication, DNA repair and recombination. Moreover, many SNF2 family members have been linked to human disease and cancer. Their role in human pathologies is documented by several developmental disorders associated with mutations in SNF2 ATPase genes. In addition, SNF2 ATPases have emerged as contributing factors in a variety of human cancers. Different SNF2 ATPases play different roles in cancer: whereas some act as tumour suppressors, others have oncogenic functions.
We are also interested in identifying novel factors involved in the maintenance of genome stability outside of the SNF2 ATPase family. We use a multidisciplinary approach to study these factors at a biochemical, cellular, and physiological level. Our aim is to provide a detailed picture of their function and improve our understanding of fundamental cellular mechanisms that impact on genome stability and play a role in human disease.
研究兴趣
论文共 24 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
NUCLEIC ACIDS RESEARCHno. 2 (2024): 801-815
Marcin J Suskiewicz,Deeksha Munnur,Øyvind Strømland,Ji-Chun Yang,Laura E Easton,Chatrin Chatrin,Kang Zhu, Domagoj Baretić, Stéphane Goffinont,Marion Schuller, Wing-Fung Wu,Jonathan M Elkins,
Christopher J. Carnie, Lucy Armstrong,Marek Sebesta,Antonio Ariza, Xiaomeng Wang,Emily Graham,Kang Zhu,Dragana Ahel
CELL REPORTSno. 4 (2023): 112329-112329
Science Advancesno. 40 (2022): eadd4253-eadd4253
Nature communicationsno. 1 (2021): 4055-4055
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn