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I perform translational research into mechanisms of injury in PCI and understanding reperfusion in ST elevation myocardial injury. Initially we demonstrated the importance of Troponin elevation after PCI as it reflects new myocardial injury detected by MR imaging. . We then investigated changes in blood flow in these newly injured areas and investigated the impact of opening chronic occlusions on myocardial function.
We completed a randomised controlled trial of PCI vs CABG with evidence of new myocardial injury as the endpoint (Eurointervention January 2011). Analysis of the role of different markers of injury in this study was published by J Am Coll Cardiol 2011 with an accompanying editorial. This work helped change the biochemical definitions of revascularisation injury within subsequent trials of revascularisation strategy.
We are currently investigating how to predict outcome in ST elevation myocardial infarction and how using these novel tools we might tailor therapy for those patients most at risk of adverse outcomes.
We completed a randomised controlled trial of PCI vs CABG with evidence of new myocardial injury as the endpoint (Eurointervention January 2011). Analysis of the role of different markers of injury in this study was published by J Am Coll Cardiol 2011 with an accompanying editorial. This work helped change the biochemical definitions of revascularisation injury within subsequent trials of revascularisation strategy.
We are currently investigating how to predict outcome in ST elevation myocardial infarction and how using these novel tools we might tailor therapy for those patients most at risk of adverse outcomes.
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论文共 649 篇作者统计合作学者相似作者
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Liam S. Couch,Katharine E. Thomas,Federico Marin,Dimitrios Terentes-Printzios, Rafail A. Kotronias, Jason Chai, Elena Lukaschuk,Mayooran Shanmuganathan,Peter Kellman,Jeremy P. Langrish,Keith M. Channon,Stefan Neubauer,
JACC: Cardiovascular Imaging (2024)
CORONARY ARTERY DISEASEno. 2 (2024): 122-134
Alicia Le Bras,David Hildick-Smith, Arnaud Nze Ossima, Olivier Supplisson,Mohaned Egred,Philippe Brunel,Adrian P. Banning,Marie-Claude Morice,Isabelle Durand-Zaleski
OPEN HEARTno. 1 (2024)
Nature reviews. Cardiologypp.1-2, (2024)
Circulation. Cardiovascular interventionsno. 4 (2024): e013675-e013675
Journal of the Society for Cardiovascular Angiography & Interventionspp.101288, (2024)
Heart (British Cardiac Society)no. 7 (2024): 500-507
Journal of the American College of Cardiologyno. 11 (2024): 1073-1081
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