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My group studies the molecular basis of two related neurodegenerative diseases: frontotemporal dementia (FTD) and motor neuron disease (MND). FTD is a common form of young-onset dementia and is characterised by changes in personality and language. MND is characterised by progressive weakness and paralysis. FTD and MND can be caused by mutations in the same gene, and can co-occur in the same individual. Therefore, FTD and MND are now considered overlapping clinical syndromes with common causes.
Our approach is to generate cellular and animal models of genetically inherited forms of FTD and MND, in parallel with analysis of patient iPSC-neurons and brain tissue, in order to elucidate the mechanisms that lead to neuronal dysfunction and death. We are also developing drug screens based on this knowledge to identify potential therapeutics. Our main focus is on two disease genes, CHMP2B and C9orf72.
Our approach is to generate cellular and animal models of genetically inherited forms of FTD and MND, in parallel with analysis of patient iPSC-neurons and brain tissue, in order to elucidate the mechanisms that lead to neuronal dysfunction and death. We are also developing drug screens based on this knowledge to identify potential therapeutics. Our main focus is on two disease genes, CHMP2B and C9orf72.
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Carmelo Milioto, Mireia Carcolé, Ashling Giblin,Rachel Coneys, Olivia Attrebi,Mhoriam Ahmed,Samuel S. Harris, Byung Il Lee, Mengke Yang, Robert A. Ellingford, Raja S. Nirujogi,Daniel Biggs,
Nature Neurosciencepp.1-13, (2024)
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biorxiv(2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin,Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed,Samuel S Harris, Byung Il Lee, Mengke Yang, Robert A Ellingford, Raja S Nirujogi,Daniel Biggs,
Nature neuroscience (2024)
Carmelo Milioto, Mireia Carcole, Ashling Giblin,Rachel Coneys, Olivia Attrebi,Mhoriam Ahmed,Samuel S. Harris, Byung Il Lee, Mengke Yang, Robert A. Ellingford, Raja S. Nirujogi,Daniel Biggs,
NATURE NEUROSCIENCE (2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin,Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed,Samuel S. Harris, Byung Il Lee, Mengke Yang, Robert A. Ellingford, Raja S. Nirujogi,Daniel Biggs,
Nature Neurosciencepp.1-13, (2024)
Ashling Giblin, Alexander J Cammack,Niek Blomberg, Alla Mikheenko, Mireia Carcole, Rachel Coneys, Lele Zhou,Yassene Mohammed, Damien Olivier-Jimenez, Magda L Atilano,Teresa Niccoli,Alyssa N Coyne,
biorxiv(2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin,Rachel Coneys, Olivia Attrebi,Mhoriam Ahmed,Samuel S. Harris, Byung Il Lee, Mengke Yang, Raja S. Nirujogi,Daniel Biggs, Sally Salomonsson,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Björn F. Vahsen, Sumedha Nalluru, Georgia R. Morgan,Lucy Farrimond,Emily Carroll,Yinyan Xu,Kaitlyn M. L. Cramb, Benazir Amein,Jakub Scaber,Antigoni Katsikoudi,Ana Candalija, Mireia Carcolé,
Nature communicationsno. 1 (2023): 5898-16
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