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The Saiardi lab is interested in the intersection between signalling and basic metabolism. Specifically, we study the role played by inositol pyrophosphates in maintaining cell homeostasis.
Inositol pyrophosphates are present in all eukaryotic cells and belong to the inositol phosphate family of soluble signaling molecules. Both inositol phosphates and inositol pyrophosphates are obtained by the combinatorial attachment of phosphate groups to inositol. However, the inositol pyrophosphates are distinguished by their one or more high-energy phosphoanhydride bonds (pyro-moieties). The energy stored in these bonds provides the inositol pyrophosphates with the potential to take part in new and not yet fully understood molecular actions.
The structure of these molecules and their conservation in eukaryotic biology suggests a fundamental signalling role, acting through a unique mechanism. Alteration of inositol pyrophosphate levels has been associated with a wide collection of phenotypes as well as important human pathology such as obesity, diabetes and cancer. These pleiotropic effects suggest an ability to control a central cellular function.
Our finding that inositol pyrophosphates regulate intracellular levels of ATP places these molecules at the interface between signalling and basic metabolism. Research in our lab focuses on understanding how inositol pyrophosphates regulate basic metabolism.
研究兴趣
论文共 186 篇作者统计合作学者相似作者
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Betül Haykir, Seraina Olivia Moser,Eva Maria Pastor-Arroyo,Udo Schnitzbauer, Zsuzsa Radvanyi,Isabel Prucker,Danye Qiu, Dorothea Fiedler,Adolfo Saiardi,Henning J Jessen,Nati Hernando,Carsten A Wagner
Journal of the American Society of Nephrology : JASN (2024)
biorxiv(2024)
Guangning Zong,Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon,Adolfo Saiardi,Stephen B. Shears,Huanchen Wang
The EMBO journalno. 3 (2024): 462-480
Tania Maffucci,Enza Piccolo, Albana Cumashi,Manuela Iezzi,Andrew M. Riley,Adolfo Saiardi, H. Yasmin Godage,Cosmo Rossi,Massimo Broggini,Stefano Iacobelli,Barry V.L. Potter, Paolo Innocenti,
crossref(2023)
RSC chemical biologyno. 4 (2023): 300-309
Biochemical Society transactionsno. 5 (2023): 1947-1956
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Tania Maffucci,Enza Piccolo, Albana Cumashi,Manuela Iezzi,Andrew M. Riley,Adolfo Saiardi, H. Yasmin Godage,Cosmo Rossi,Massimo Broggini,Stefano Iacobelli,Barry V.L. Potter, Paolo Innocenti,
crossref(2023)
Verena B. Eisenbeis,Danye Qiu,Oliver Gorka, Lisa Strotmann,Guizhen Liu, Isabel Prucker,Xue Bessie Su,Miranda S. C. Wilson,Kevin Ritter,Christoph Loenarz,Olaf Gross,Adolfo Saiardi,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 34 (2023): e2306868120-e2306868120
Tania Maffucci,Enza Piccolo, Albana Cumashi,Manuela Iezzi,Andrew M. Riley,Adolfo Saiardi, H. Yasmin Godage,Cosmo Rossi,Massimo Broggini,Stefano Iacobelli,Barry V.L. Potter, Paolo Innocenti,
crossref(2023)
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