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Dr. Najafi-Shoushtari’s research interests focus on gene regulation by non-coding RNAs. His efforts have been dedicated to understanding the role of microRNAs in cholesterol/lipid homeostasis with an emphasis on defining new mechanisms of major human diseases associated with obesity, type 2 diabetes and cardiovascular disorders. His discovery of the role and function of miR-33 in regulating plasma HDL levels has led more recently to the development of novel potential therapeutic strategies for the treatment of abnormal lipid levels. He combines genetics, biochemistry, genomics, and computational tools to map critical points for metabolic control by microRNAs and to explore how these molecules involved are connected and orchestrated at the systems-level with emphasis on clinical relevance and implications in cardiometabolic disease.
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BMC Medical Genomicsno. 1 (2023): 301-301
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