基本信息
浏览量:229
职业迁徙
个人简介
Modern genomic technologies make it relatively easy to generate rich data sets describing genome sequences, RNA expression, chromatin states, and many other aspects of the storage, transmission, and expression of genetic information. For many problems in genetics today, the limiting step is no longer in data generation, but in integrating, interpreting, and understanding the available data. Addressing these challenges requires expertise both in the practical arts of data analysis and in the theoretical underpinnings of statistics, computer science, and genetics.
My group focuses on a diverse collection of research questions in this interdisciplinary area, spanning applications in cancer biology, basic molecular biology, evolutionary genetics, infectious diseases, and agriculture. Over the years, our research has touched on topics including the identification of recombinant strains of HIV, the discovery of new human genes, the characterization of conserved regulatory elements in mammalian genomes, the identification of noncoding mutations important in cancer, and the discovery of ancient gene flow from humans to Neandertals. A general theme in our work is the development of precise mathematical models for the complex processes by which genomes evolve over time, and the use of these models, together with techniques from computer science and statistics, both to peer into the past, and to address questions of practical importance for human health. We collaborate closely with experimentalists in cancer biology, transcriptional regulation, plant breeding and many other areas.
研究兴趣
论文共 168 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Jenelys Ruiz Ortiz,Steven M. Lewis,Michael Ciccone, Deeptiman Chatterjee,Samantha Henry,Adam Siepel,Camila O. dos Santos
Journal of Mammary Gland Biology and Neoplasiano. 1 (2024): 3-3
CANCER RESEARCHno. 3 (2024)
bioRxiv : the preprint server for biology (2023)
bioRxiv : the preprint server for biology (2023)
Benjamin Berube, Evan Ernst, Jonathan Cahn,Benjamin Roche, Cristiane de Santis Alves,Jason Lynn,Armin Scheben,Adam Siepel,Jeffrey Ross-Ibarra,Jerry Kermicle,Rob Martienssen
biorxiv(2023)
引用0浏览0引用
0
0
bioRxiv (Cold Spring Harbor Laboratory) (2023)
NUCLEIC ACIDS RESEARCHno. 21 (2023): e106-e106
Lukas F K Kuderna,Jacob C Ulirsch, Sabrina Rashid, Mohamed Ameen,Laksshman Sundaram,Glenn Hickey,Anthony J Cox, Hong Gao, Arvind Kumar,Francois Aguet,Matthew J Christmas,Hiram Clawson,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn