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Yonath focuses on the mechanisms underlying protein biosynthesis, by ribosomal crystallography, a research line she pioneered over twenty years ago despite considerable skepticism of the international scientific community. Ribosomes translate RNA into protein and because they have slightly different structures in microbes, when compared to eukaryotes, such as human cells, they are often a target for antibiotics. In 2000 and 2001, she determined the complete high-resolution structures of both ribosomal subunits and discovered within the otherwise asymmetric ribosome, the universal symmetrical region that provides the framework and navigates the process of polypeptide polymerization. Consequently, she showed that the ribosome is a ribozyme that places its substrates in stereochemistry suitable for peptide bond formation and for substrate-mediated catalysis. In 1993 she visualized the path taken by the nascent proteins, namely the ribosomal tunnel, and recently revealed the dynamics elements enabling its involvement in elongation arrest, gating, intra-cellular regulation and nascent chain trafficking into their folding space.
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论文共 180 篇作者统计合作学者相似作者
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K. Shanmugha Rajan, Hava Madmoni,Anat Bashan,Masato Taoka,Saurav Aryal,Yuko Nobe,Tirza Doniger, Beathrice Galili Kostin, Amit Blumberg,Smadar Cohen-Chalamish,Schraga Schwartz, Andre Rivalta,
Nature Communicationsno. 1 (2023): 1-16
Biomedicinesno. 9 (2023): 2541-2541
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Israel Journal of Chemistryno. 11-12 (2021): 863-872
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSno. SUPPL 1 (2021): 39-39
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Proceedings of the National Academy of Sciences of the United States of Americano. 46 (2021)
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