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Immunobiology of Aging. Aging has two faces. One face pertains to age-related physiologic damage; hence we are investigating the immunology of frailty, a discrete clinical syndrome in which affected elders (defined as 65 years and older) are functionally dependent on others for their activities of daily living. The other, less studied face of aging is successful aging, exemplified by community dwelling elders who are highly functional despite long history of diseases and/or concurrent co-morbid conditions. We are interested in the fundamental question: What are the immunologic determinants of long-term survivorship? Seeking answer(s) to this question requires a research paradigm shift from the usual young-vs-old comparisons to cursory evaluation of clinically-defined groups of elders. To complement these human studies, we also are examining a mouse model of successful aging, the PAPPA-/- mouse, a novel strain that has 40% extension in lifespan, has low levels of midlife/late life pathology, and is resistant to age-associated thymic atrophy.
Immunobiology of Aging. Aging has two faces. One face pertains to age-related physiologic damage; hence we are investigating the immunology of frailty, a discrete clinical syndrome in which affected elders (defined as 65 years and older) are functionally dependent on others for their activities of daily living. The other, less studied face of aging is successful aging, exemplified by community dwelling elders who are highly functional despite long history of diseases and/or concurrent co-morbid conditions. We are interested in the fundamental question: What are the immunologic determinants of long-term survivorship? Seeking answer(s) to this question requires a research paradigm shift from the usual young-vs-old comparisons to cursory evaluation of clinically-defined groups of elders. To complement these human studies, we also are examining a mouse model of successful aging, the PAPPA-/- mouse, a novel strain that has 40% extension in lifespan, has low levels of midlife/late life pathology, and is resistant to age-associated thymic atrophy.
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Mark H Kuniholm, Mariam Bramah-Lawani,Meghan Fitzpatrick,Mehdi Nouraie,Shulin Qin,Laurence Huang,Abbe N Vallejo,Alan L Landay,Alison Morris
Abbe N Vallejo, Henry J Mroczkowski,Joshua J Michel, Michael Woolford,Harry C Blair,Patricia Griffin, Elizabeth McCracken,Stephanie J Mihalik,Miguel Reyes-Mugica,Jerry Vockley
Clinical & translational immunologyno. 6 (2021): e1304-e1304
Kumaravel Rajakumar,Charity G Moore, Arshad T Khalid,Abbe N Vallejo, Mohamed A Virji,Michael F Holick,Susan L Greenspan,Silva Arslanian,Steven E Reis
Handbook of Immunosenescencepp.449-481, (2019)
Frontiers in immunology (2016): 530-530
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