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Dr Alexander-Bloch investigates normal brain development and the altered developmental trajectories that lead to mental illness, using a multi-disciplinary approach that integrates brain imaging, genomics and clinical information. The lab team's goal is to translate the highly polygenic risk for psychosis and other neurodevelopmental psychiatric disorders into pathophysiologic mechanisms, to inform therapeutic targets and improve risk assessment. Current projects include: 1) Lifespan trajectory models of post-mortem brain gene expression and brain MRI morphological features (n=100,000 scans including shared and open data); 2) Influence of copy number variants and polygenic risk on brain development and psychiatric risk, in the Philadelphia Neurodevelopmental Cohort; 3) Analysis of clinically-acquired brain MRI at CHOP and integration with natural language processing of physician notes from electronic health record; 4) Transcriptome-wide association study of neuroimaging phenotypes in the UK Biobank. Rotation Projects are available within the scope of each of the above projects.
Dr Alexander-Bloch investigates normal brain development and the altered developmental trajectories that lead to mental illness, using a multi-disciplinary approach that integrates brain imaging, genomics and clinical information. The lab team's goal is to translate the highly polygenic risk for psychosis and other neurodevelopmental psychiatric disorders into pathophysiologic mechanisms, to inform therapeutic targets and improve risk assessment. Current projects include: 1) Lifespan trajectory models of post-mortem brain gene expression and brain MRI morphological features (n=100,000 scans including shared and open data); 2) Influence of copy number variants and polygenic risk on brain development and psychiatric risk, in the Philadelphia Neurodevelopmental Cohort; 3) Analysis of clinically-acquired brain MRI at CHOP and integration with natural language processing of physician notes from electronic health record; 4) Transcriptome-wide association study of neuroimaging phenotypes in the UK Biobank. Rotation Projects are available within the scope of each of the above projects.
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Kaidi Kang,Jakob Seidlitz,Richard A.I. Bethlehem,Jiangmei Xiong, Megan T. Jones, Kahini Pankaj Mehta, Arielle Keller,Ran Tao, Anita Randolph, Bart Larsen, Brenden Tervo-Clemmens, Eric J Feczko,
biorxiv(2024)
Kun Zhao,Pindong Chen,Aaron Alexander-Bloch,Yongbin Wei, Martin Dyrba, Fan Yang,Xiaopeng Kang,Dawei Wang,Dongsheng Fan,Shan Ye,Yi Tang,Hongxiang Yao,
Proceedings of the National Academy of Sciences of the United States of Americano. 20 (2023)
Nature Neuroscienceno. 4 (2023): 638-649
CELL REPORTSno. 11 (2023): 113439-113439
medRxiv : the preprint server for health sciences (2023)
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