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Eukaryotic cells adapt to environmental changes by altering their protein complements through synthesis and degradation. Cells that adapt poorly or improperly may either cease to exist (e.g., apoptosis) or become neoplastic (e.g., hepatoma). Cells adapt to low levels of amino acids by sequestering proteins and organelles for lysosomal degradation via a process called autophagy. The data suggest that autophagy protects the cells from nutrient, environmental, and chemical stresses that may cause cell death. Autophagy-mediated cell protection is likely mediated by the degradation of damaged mitochondria, which otherwise would promote cell death via apoptosis. The ability of autophagy to remove and degrade damaged mitochondria also suggests that autophagy may have a beneficial role in aging. Furthermore, cancers that effectively regulate autophagy have the potential to resist chemotherapy agents and thrive.
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论文共 65 篇作者统计合作学者相似作者
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Thomas Biel,Joseph A. Flores-Toro,Joseph W. Dean, Min-Ho Lee,William A. Dunn,Ivan Zendejas,Kevin E. Behrns,Jae-Sung Kim
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Jessica Nicks,Sooyeon Lee,Andrew Harris,Darin J Falk,Adrian G Todd, Karla Arredondo,William A Dunn,Lucia Notterpek
Neurobiology of disease (2014): 224-36
John P Aris,Ashley L Alvers,Roy A Ferraiuolo,Laura K Fishwick,Amanda Hanvivatpong,Doreen Hu,Christine Kirlew,Michael T Leonard, Kyle J Losin,Michelle Marraffini,Arnold Y Seo, Veronica Swanberg,
Autophagy and Cancerpp.1-24, (2013)
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