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The volume of genomic testing is expected to increase given the large federal and commercial investment in genomic technologies designed to enhance personalized medicine. Translational research that evaluates the implementation, dissemination and “real world” outcomes of existing and new genomic applications is needed to guide the rational clinical integration of genomic advances to ultimately reduce the burden of cancer and improve human health. As a medical oncologist with specialized training in clinical cancer genetics, cancer prevention and medical ethics, I have been developing and leading translational genetic research focused on the ethics and clinical implementation of genetic medicine to promote the health of individuals and families since 2003. This work involves research and academic activities focused on: a) the delivery of genetic services, b) the implications of genetic medicine for children and adolescents and c) Ethical, Legal and Social Issues in genetic medicine. These translational and multidisciplinary studies (further described below) have been supported by the National Institutes of Health, American Cancer Society, Greenwall Foundation Program in Bioethics, American Society of Clinical Oncology and Pennsylvania Department of Health. We expect these studies, and subsequent studies within this research program to increase our understanding of how to incorporate genomic testing into the care of patients and families in a way that benefits the health and minimizes the risks for patients across the lifespan.
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Alexandra Torres, Megan Aaron, Lia White, Kurt D'Andrea,Vivek Narayan, Hayley Michelle Knollman,Angela R. Bradbury,Nadine M. Tung,Mark E. Robson,Katherine Nathanson,Susan M. Domchek,Payal Deepak Shah
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JOURNAL OF CLINICAL ONCOLOGYno. 31 (2023): 4905-+
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