基本信息
浏览量:7
职业迁徙
个人简介
The research in my laboratory mainly investigates how pathogen interaction with the innate immune system influences the development of adaptive immunity and inflammation. My particular interest is Type 2 inflammation, which is responsible for widespread suffering in allergy, as well as being a hallmark of infection with parasitic worms (helminths).
Our research uses a combination of in vivo and in vitro model systems, focussing on the medically important helminth Schistosoma mansoni. Murine infection with this parasite provides a relevant experimental model of Type 2 inflammation that has been used extensively by my laboratory and others to reveal important cellular and molecular players and processes during hepatic, intestinal and pulmonary inflammation. Our current experimental focus in this area is on the immune features that dominate in the lungs and intestines at different stages of infection, and interplay between the parasite and the host microbiota.
Our research uses a combination of in vivo and in vitro model systems, focussing on the medically important helminth Schistosoma mansoni. Murine infection with this parasite provides a relevant experimental model of Type 2 inflammation that has been used extensively by my laboratory and others to reveal important cellular and molecular players and processes during hepatic, intestinal and pulmonary inflammation. Our current experimental focus in this area is on the immune features that dominate in the lungs and intestines at different stages of infection, and interplay between the parasite and the host microbiota.
研究兴趣
论文共 130 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Emma Louise Houlder,Sara Gago,George Vere,Daniel Conn,Saba Khan,Darren Thomson, Mark Shepherd, Ressa Lebedinec,Gordon D Brown,Michael Bromley,Andrew S MacDonald,Peter C Cook
biorxiv(2024)
Luke W. Desmond, Evan M. Holbrook, Caelan T. O. Wright,Cristian A. Zambrano, Christopher E. Stamper,Adam D. Bohr,Matthew G. Frank,Brendan K. Podell,Julie A. Moreno,Andrew S. MacDonald,Stefan O. Reber,Rogelio Hernandez-Pando,
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 1 (2024): 474
Stefano A P Colombo,Sheila L Brown,Matthew R Hepworth,Jenny Hankinson, Felice Granato, Semra J Kitchen,Tracy Hussell,Angela Simpson,Peter C Cook,Andrew S MacDonald
Discovery immunologyno. 1 (2023): kyad009-kyad009
E. L. Houlder, A. H. Costain, I. Nambuya, S. L. Brown, J. P. R. Koopman, M. C. C. Langenberg, J. J. Janse, M. A. Hoogerwerf, A. J. L. Ridley, J. E. Forde-Thomas, S. A. P. Colombo, B. M. F. Winkel,
Nature Communicationsno. 1 (2023): 1-12
Thomas Kisby, Mario Stylianou, D Despotopoulou,Helen Parker, Alexandra Jade Thawley, Nicolas Lozano,Andrew S. MacDonald,Kostas Kostarelos
Neuro-Oncologyno. Supplement_2 (2023): ii48-ii48
引用0浏览0引用
0
0
bioRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
CANCER RESEARCHno. 8 (2023)
crossref(2023)
FRONTIERS IN IMMUNOLOGY (2023)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn