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Molecular mechanisms of cancer biology: Our lab is interested in molecular mechanisms of cancer biology, particularly concerning members of the Ras superfamily of proteins. Ras proteins are the prototypes for a large superfamily of related small GTPases whose activity is regulated by a cycle of GTP/GDP binding and subcellular localization, and whose diverse functions in cellular physiology include growth, invasion, motility, cell cycle control, differentiation and death. Whereas normal signal transduction by Ras family proteins is required for proper cell growth and differentiation resulting from a wide variety of different inputs, their malfunction or deregulated activity is linked to uncontrolled cell proliferation or inappropriate cell suicide. Indeed, mutated Ras genes are the most commonly mutated oncogenes in human cancer, and their deregulated function as a consequence of alterations in other proteins is also a critical mechanism driving many cancer cells. In our lab, studying the mechanisms whereby mammalian Ras family proteins and their cousins control the conversion of extracellular signals to intracellular responses provides us with several broad areas of experimentation with both basic science and translational bents.
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论文共 213 篇作者统计合作学者相似作者
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Wen-Hsuan Chang, Addison G. Stamey,Andrew M. Waters,Kirsten L. Bryant,Adrienne D. Cox,Channing J. Der
Cancer Researchno. 6_Supplement (2024): 1936-1936
Kristina Drizyte-Miller,Wen-Hsuan Chang,Andrew M. Waters,Clint A. Stalnecker,Junning Wang,Andrew J. Aguirre,Adrienne D. Cox,Channing J. Der
Cancer Researchno. 6_Supplement (2024): 4588-4588
Jonathan M. DeLiberty, Mallory K. Roach,Noah L. Pieper,Kristina Drizyte-Miller, Elyse G. Schechter,Runying Yang,Channing J. Der,Adrienne D. Cox,Clint A. Stalnecker,Kirsten L. Bryant
CANCER RESEARCHno. 2 (2024): 4851-4851
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
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Haisheng Zhang,Antje Schaefer, Yichen Wang,Richard G. Hodge,Devon R. Blake,J. Nathaniel Diehl,Alex G. Papageorge,Matthew D. Stachler, Jennifer Liao,Jin Zhou,Zhong Wu, Fahire G. Akarca,
crossref(2023)
CANCER RESEARCHno. 7 (2023)
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Alexander C. Edwards,Clint A. Stalnecker, Alexis J. Morales, Khalilah E. Taylor,Jill Hallin,Peter Olson,Tracy T. Tang,Lars Engstrom,Leonard Post,James G. Christensen,Adrienne D. Cox,Channing J. Der
MOLECULAR CANCER RESEARCHno. 5 (2023)
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Jennifer E. Klomp,Jeff Klomp,Nathaniel J. Diehl,Cole A. Edwards,Kristina Drizyte‐Miller,Priya S. Hibshman,Runying Yang, Alexis J. Morales, Khalilah E. Taylor,Mariaelena Pierobon,Emanuel F. Petricoin,Johnson L. Jared,
Molecular Cancer Researchno. 5_Supplement (2023): B034-B034
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