基本信息
浏览量:218
职业迁徙
个人简介
My research is focused on two R01-funded projects: first, my group has developed a pancreatic cancer immunotherapy research program on a neoadjuvant therapy platform and also a number of preclinical models of pancreatic cancer for developing innovative immunotherapy strategies. My group has also applied the knowledge gained from pancreatic cancer immune-based therapies to the development of a colorectal cancer GVAX vaccine. Second, my group is aimed at understanding the mechanistic roles of tumor microenvironment in cancer development and metastasis and identifying new targets for pancreatic cancer therapies by dissecting tumor microenvironment of pancreatic cancer. Specifically, my laboratory found that the induction of antibodies against annexin A2 (AnxA2) in the sera of pancreatic ductal adenocarcinoma (PDA) patients is associated with longer recurrence-free survival following the GVAX vaccine therapy. By knocking out AnxA2 in a transgenic mouse model of PDA that recapitulates the progression of human PDA from premalignancy to metastatic disease, we found that AnxA2 is essential for metastases in vivo. More recently, my laboratory found the expression of semaphorin 3D (Sema3D) and plexin D1 (PlxnD1), which mediate the migration of neuronal axons during development and of blood vessels during angiogenesis, is increased in pancreatic cancer. Our study subsequently elucidated a novel mechanism of PDA metastasis formation that is mediated by AnxA2-dependent Sema3D secretion and subsequent autocrine activation of PlxnD1, the receptor of Sema3D. Studies are underway to uncover the exact processes by which Sema3D and PlxnD1 induce invasion of PDA cells from the primary tumor site into the surrounding blood vessels, nerves and lymphatic vessels. My group is also developing therapeutic agents that target AnxA2 and Sema3D for pancreatic cancer treatment.
研究兴趣
论文共 417 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Gastroenterologyno. 5 (2024): S-1338
Samantha Guinn,Benedict Kinny-Köster, Joseph A. Tandurella,Jacob T. Mitchell,Dimitrios N. Sidiropoulos,Melanie Loth,Melissa R. Lyman,Alexandra B. Pucsek,Daniel J. Zabransky,Jae W. Lee, Emma Kartalia, Mili Ramani,
crossref(2024)
Marc Wehrli,Samantha Guinn,Filippo Birocchi, Adam Kuo,Yi Sun,Rebecca C. Larson, Antonio J. Almazan,Irene Scarfò,Amanda A. Bouffard,Stefanie R. Bailey, Praju Vikas Anekal,Paula Montero Llopis,
crossref(2024)
Marc Wehrli,Samantha Guinn,Filippo Birocchi, Adam Kuo,Yi Sun,Rebecca C. Larson, Antonio J. Almazan,Irene Scarfò,Amanda A. Bouffard,Stefanie R. Bailey, Praju Vikas Anekal, Paula Montero Llopis,
crossref(2024)
Marc Wehrli,Samantha Guinn,Filippo Birocchi, Adam Kuo,Yi Sun,Rebecca C. Larson, Antonio J. Almazan,Irene Scarfò,Amanda A. Bouffard,Stefanie R. Bailey, Praju Vikas Anekal,Paula Montero Llopis,
crossref(2024)
Nature Cancerno. 2 (2024): 299-314
Marc Wehrli,Samantha Guinn,Filippo Birocchi, Adam Kuo,Yi Sun,Rebecca C. Larson, Antonio J. Almazan,Irene Scarfò,Amanda A. Bouffard,Stefanie R. Bailey, Praju Vikas Anekal, Paula Montero Llopis,
crossref(2024)
Marc Wehrli,Samantha Guinn,Filippo Birocchi, Adam Kuo,Yi Sun,Rebecca C. Larson, Antonio J. Almazan,Irene Scarfò,Amanda A. Bouffard,Stefanie R. Bailey, Praju Vikas Anekal, Paula Montero Llopis,
crossref(2024)
Junke Wang, Jessica Gai, Tengyi Zhang,Nan Niu, Hanfei Qi,Dwayne L. Thomas,Keyu Li,Tao Xia,Christina Rodriguez,Rose Parkinson,Jennifer Durham, Thomas Mcphaul,
SCIENCE ADVANCESno. 6 (2024)
Marc Wehrli,Samantha Guinn,Filippo Birocchi, Adam Kuo,Yi Sun,Rebecca C Larson, Antonio J Almazan,Irene Scarfò,Amanda A Bouffard,Stefanie R Bailey, Praju Vikas Anekal, Paula Montero Lopis,
Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn