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个人简介
Dr. Lin’s clinical expertise lies in the diagnosis and treatment of diabetic retinopathy, age-related macular degeneration (AMD), and other retinal vascular diseases. As a clinician-scientist, Dr. Lin’s lab primarily focuses on epigenetic mechanisms of disease, gene-editing, and stem cell tissue regeneration, as well as gene therapy approaches for AMD and diabetic retinopathy. To date, Dr. Lin has identified several genes involving ubiquitin conjugation and de-ubiquitination, created a de novo DNA methyl-transferase gene knockout and induction mice, and studied the function of DNA methylation in tumor formation. He demonstrated the function of microRNA in the development of AMD before people cast eyes over this non-coding RNA in this field, and was one of the pioneers who found that mitochondrial DNA (mtDNA) damage is associated with AMD. and is currently exploring gene therapy using adenoviruses and non-vial vectors for the treatment of inherited retinal diseases like AMD.
研究兴趣
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Mengtian Cui,Shun-Yun Cheng,Qin Su, Joae Wu, Jackson McGowan,Brian Rossmiller,Meiyu Xu,Guangchao Xu, Li Luo,Wanru Qin,Bo Tian,Yuquan Wei,
MOLECULAR THERAPYno. 4 (2023): 179-179
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Ophthalmology Scienceno. 1 (2023): 100206-100206
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